Women’s Health

Bioidentical Hormones, Menopause, Libido and more…

Medical Aesthetics

Botox, Fillers, Chemical Peels and more…

Men’s Health

Hormone Replacement, Stress Management, Weightloss…

Helping Men, Women and Children Live Better Lives

Contact us today to get started


10 year anniversary

Hear Dr. Matthew explain our approach to wellness.

Dr. Matthew and her team at Signature Wellness strive to help people achieve optimal health so they may enjoy the best quality of life today, minimize risks for chronic disease and preserve an excellent quality of life for the future.

Signature Wellness integrates established medical concepts, emerging science and evidence-based nutritional medicine to create a personalized, pro-active plan to enhance health and help prevent disease.

Dr. Matthew’s medical area of focus is bio-identical hormone replacement for Men & Women. While well known locally as a pioneer in Medical Wellness, she has also been featured in New You magazine an international publication and she is also frequently invited to speak at Medical conferences nationally and internationally.  In addition, she authored a best selling book on hormone balance and was the medical editor for another book on HRT.

“Take good care of your future because
that’s where you’re going to spend the rest of your life.”
– K. Kettering

By Design – Exclusive. Unrushed. Personalized.

Dr. Matthew -  invited expert speaker in Bangkok, Thailand 2013

deborah matthew charlotte bioidentical hormone doctor invited to Bali

Dr. Matthew - invited to Bali as an expert examiner and speaker in 2013.

Dr.Matthew lecturing in Dubai 2015

 Dr. Matthew gives a lecture in Las Vegas 2015

Dr.Matthew Interviewed by Simply Health TV

Dr.Matthew - Lecture in Las Vegas - Dec 2014

Dr.Matthew invited examiner in Dubai 2014

Speaking on BHRT in Las Vegas 2013

Oshot Charlotte O-shot

Dr. Matthew & Dr. Runels (Inventor of Vampire Lift}

Dr. Matthew : Invited Expert Speaker - Florida | May 2015

Disclaimer: The information on this website has not been evaluated by the FDA. This information is not intended to treat diagnose, cure or prevent any disease. All material provided on this web site and links are for educational purposes only. None of the information on this web site should be taken as medical advice and is in no way a substitution for professional medical care. We recommend you consult with a physician before starting any health program. Signature Wellness PA disclaims responsibility and liability for any harm resulting from the use or misuse of any information on this site.

No treatment, treatment advice, exercise or nutritional advice if followed can be guaranteed to work in everyone nor can they be considered absolutely safe. Individual response to treatment and unexpected responses can affect outcomes. Individual results vary. Reputable physicians do not guarantee outcomes and no prediction of outcome is implied.