About Us

Why Patients Choose Dr. Matthew and Signature Wellness.

Training and Dedication

Dr. Matthew has a history of high achievement including an additional year of study towards a Masters in Physiology, top 10th percentile scores for Medical School and Residency in national testing, and the distinction of being selected as Chief Resident in Pediatrics by Tuft’s University Faculty. That same commitment has led to Signature Wellness being award the distinction as a TLC Center of Excellence.


Dr. Matthew has also completed a fellowship in Anti-Aging, Regenerative and Functional Medicine and has passed both written and oral exams  administered by the American Academy of Anti-Aging and Regenerative Medicine (A4M).  She has also completed an advanced fellowship in Functional Medicine.


In addition, she is also a diplomat of the American Board of Holistic and Integrative Medicine.  Dr. Matthew is President of the NC Integrative Medical Society.  Her additional accomplishments include authoring an Amazon best seller on hormone imbalance, acting as the medical editor for a book on hormone replacement for women, guest speaking at multiple international conferences  in places like Thailand, Indonesia, Dubai, and many locations throughout the U.S. such as Chicago, Washington, Miami, Las Vegas and more. She is considered an expert in her field, and functions as an expert oral Board examiner for the A4M and IFM. The A4M and Institute of Functional Medicine are non profit educational organizations and are not affiliated with the American Board of Medical Specialties. Dr. Matthew also trains and proctors medical providers on medical treatment and office procedures.


Privacy and Respect for Time

Dr. Matthew treats professionals such as physicians, attorneys, engineers, accountants and executives. She appreciates that their time and privacy is as important as their health. As an independent medical practice she is better able to respect these concerns.

We Exist for You

As an independent,  and non-corporate practice, we are able to meet the needs of our patients without reporting to ‘management’. We report to you.  Since 2006, our priority and mission has been to provide exceptional care in a manner that Dr. Matthew herself would want as a patient.

Meaningful Education

We encourage questions and discussion so that you can make an informed decision that is right for you. Many of our patients are well read and have done their own research before choosing our office.  We offer monthly educational seminars, the Hormone Makeover book, and provide thorough education during appointments to ensure our patients have the information they need.

Comprehensive Programs

We offer comprehensive programs that include thorough evaluations, individualized planning and ongoing support to maintain progress toward your goals, whatever they may be.

Signature Wellness does not replace your primary care physician.


Exceptional Staff

Dr. Matthew has assembled a highly accomplished and dedicated medical staff to service the patients at Signature Wellness.


Abraham Lincoln perhaps said it best:

“It’s not the years in your life that count, it’s the life in your years.”


Deborah Matthew MD

Wellness for Men, Women and Children

President – NC Integrative Medical Society

Advanced Fellow Functional Medicine

Diplomat of the American Board of Anti-

   Aging & Regenerative Medicine (A4M)

Diplomat of the American Board of

   Integrative & Holistic Medicine (ABIHM)

Oral Examiner for A4M

Medical Director


Staci Burrell FNP

ANCC Board Certified Family Nurse Practitioner


Marci Scott ND

Patient Educator, Naturopath


Heather Baerga RN BSN

Aesthetic & Wellness Nurse


Dee Langford APRN – BC

Adult Psychotherapist


Debbie Dalessandro RN, BSN 

Wellness Educator, Health Coach



Disclaimer: The information on this website has not been evaluated by the FDA. This information is not intended to treat diagnose, cure or prevent any disease. All material provided on this web site and links are for educational purposes only. None of the information on this web site should be taken as medical advice and is in no way a substitution for professional medical care. We recommend you consult with a physician before starting any health program. Signature Wellness PA disclaims responsibility and liability for any harm resulting from the use or misuse of any information on this site.

No treatment, treatment advice, exercise or nutritional advice if followed can be guaranteed to work in everyone nor can they be considered absolutely safe. Individual response to treatment and unexpected responses can affect outcomes. Individual results vary. Reputable physicians do not guarantee outcomes and no prediction of outcome is implied.